TMDX-Somerville — File 25-1606

November 2025 TransMedics and The City of Somerville A Partnership for Innovation and Shared Growth

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TransMedics’ Unique & Integrated Approach to Solving Transplant Issues 3 Founded in 1998 – Headquartered in Andover MA Transforming organ transplantation therapy globally Listed on NASDAQ “TMDX” since 2019 - ~$4+Billion market cap

4 Transplant Challenges – Massive Underutilization of Donor Organs for Transplants DCD Donors DBD Donors Source: 2024 OPTN US National Data DBD Transplants DBD Transplants DBD Transplants 16,989 3,314 4,085 10,393 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 16,000 18,000 Total Deceased Donors in 2024 Lung Transplants Heart Transplants Liver Transplants Lungs Hearts Livers Donors Significant Opportunity to Grow Transplant Volumes

5 Historical Organ Preservation Method & Limitations Cold Storage ▪Severe time dependent injury (Ischemia) – Time & distance limitations ▪No organ optimization or improvement capabilities – Limits utilization ▪No assessment capabilities – Limits utilization & donor pool

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7 Making the Impossible Possible : Organs Alive Outside the Human Body

Source: optn.transplant.hrsa.gov/data / Company Information U.S. National Adult Transplants Heart, Lung & Liver 13,780 14,233 14,077 2,347 3,715 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 16,000 18,000 1,000 2022 2023 2024 14,780 16,580 17,792 +20% TMDX Non-TMDX 8 + 2% Excl. TMDX Turning Vision into Reality: Growing US Transplant Activity

TMDX Sustained Long-Term Growth TransMedics is entering its next phase of growth, expanding into new organs, driving increase in U.S. organ utilization, and extending our global footprint to unlock the full potential of our platform OCS Kidney OUS Expansion US Organ Utilization and OCS Adoption

10 The One-of-a-Kind TMDX Trident – End-to- End Service The One-of-a-Kind TMDX Trident – End-to- End Service Delivering Superior Clinical & Utilization Transplant Outcomes Delivering Superior Clinical & Utilization Transplant Outcomes Strong Pipeline of Technical Innovation Strong Pipeline of Technical Innovation Mission Driven Team with Proven Execution Track Record Mission Driven Team with Proven Execution Track Record Unparalleled Capabilities

11 – Administrative Team (Fin/HR/IT, etc) – Command Centers – Vivarium / Clinical Lab – R&D Labs – Manufacturing HQ 2.0 | Our Program - Draft – Flight Simulator – TMDX Aviation Leadership – TMDX Conference Center

• Strategic Location. Excellent connectivity to Boston and Cambridge through the MBTA Green Line Extension and proximity to major transportation routes • Access to Talent and Innovation. Close to leading universities and hospitals, providing access to world-class research, engineering, and medical talent. • Vibrant, Growing Community. A divers and vibrant city that values innovation, sustainability, and inclusive growth, aligned with with TransMedics’ mission and culture. • Commitment to Shared Prosperity. TransMedics is ready to contribute to the community through ongoing partnerships supporting education, safety, and overall wellbeing. Why the City of Somerville ? Somerville offers an environment where innovation, collaboration, and community converge, making it an attractive potential home for TransMedics’ new global headquarters and manufacturing facility We see Somerville as a dynamic environment where innovation, opportunity, and community thrive

• Strengthening Somerville’s Life-Science Vision. TransMedics’ presence would reinforce Somerville’s vision of becoming an emerging destination for life-science and healthcare innovation. • Job Creation and Economic Growth. Hundreds of new, high-quality jobs across corporate, manufacturing, and logistics functions—driving meaningful economic activity and local spending • Local Business Activation. Increased demand for restaurants, services, housing, and other local businesses— stimulating Somerville’s economy and strengthening its commercial ecosystem. • Community Support and Engagement. Annual contributions to education, fire, and police departments, alongside future partnerships in local schools and workforce development Examples of what TransMedics can bring to Somerville A global life-science leader anchoring growth, innovation, and community impact These benefits represent the foundation of a long-term partnership, built on innovation, shared prosperity, and a deep commitment to the Somerville community

• $100,000 – Somerville Public School District Supporting school programs, classroom resources, and student enrichment initiatives that prepare the next generation of innovators. • $50,000 – Somerville Fire Department Contributing to equipment, training, and resources to strengthen emergency response and community safety. • $50,000 – Somerville Police Department Supporting community policing and public safety programs that protect residents and local businesses. A Committed Corporate Citizen TransMedics is committed to being a long-term partner to the community that will host our new global headquarters and manufacturing facility, with a strong focus on supporting education, safety, and overall community wellbeing. If our collaboration with the City of Somerville continues to move forward, we intend to make the annual donations below to actively support and give back to the community Together with the City and the Commonwealth, we aim to bring innovation, jobs, and long-term economic growth to the community that will host our new Global Headquarter and Manufacturing Facility

16 ©️ 2024 TransMedics, Inc. Shaping the Future of Organ Transplantation